Increased Microglial Exosomal miR-124-3p Alleviates Neurodegeneration and Improves Cognitive Outcome after rmTBI.
MouseTBIControlled cortical impactC57BL/6maleIntravenous, tail vein200 microlitres PBS per mouse; exosome particle number not…35 days post-injury
Model: Repetitive mild closed-head controlled cortical impact, 5.0 m/s with 2.5 mm head displacement, four impacts at 48 hour intervals
A single tail vein injection of EXO-124 at 35 days post-injury was taken up by hippocampal neurons, suppressed Rela and restored ApoE, lowered APP and beta-amyloid, and improved water maze and novel object recognition performance.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.