THERAPY DOSSIER · th-99d0a93c7740

Ozonated olive oil (comparator arm: plain olive oil)

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound · Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07368114 ↗PHASE2completed

Validity of ozonated olive oil gel versus injectable bone graft on osseointegration of immediate dental implants

Implant Osseointegration · Ozone Therapy · Bone Graft

Enrolment: 16 · Results not recorded

NCT07265089 ↗NAnot yet recruiting

Clinical and radiographic evaluation of zinc oxide-ozonated olive oil versus Metapex as root canal filling materials in primary anterior teeth

Carious Anterior Teeth

Enrolment: 52 · Results not recorded

NCT05660343 ↗NAcompleted

Efficacy of ozonated olive oil and low-level laser therapy in the treatment of pain in individuals with temporomandibular disorder

TMD

Enrolment: 51 · Results not recorded

NCT06980675 ↗NArecruiting

Clinical and microbiological study on local application of an ozonated olive oil gel in periodontal pockets

Periodontal Pocket

Enrolment: 20 · Results not recorded

Preclinical evidence 2

2 studies reported at therapy level; 2 evidence entries itemised.

PMID 27300363 ↗2016Reported benefit

The Effect of Ozonated Olive Oil on Neovascularizatıon in an Experimental Skin Flap Model.

RatWoundWistarMalen = 21 rats allocated to 3 groupsTopical application to the flap surfaceApplied after flap elevation, for 7 days

Model: Experimental dorsal skin flap model

Mean VEGF-positive and CD34-positive microvascular structure counts were 8.86 (SD 1.35) and 10.29 (SD 1.80) in untreated controls, 15.00 (SD 1.41) and 15.57 (SD 1.72) with olive oil, and 25.14 (SD 2.41) and 25.00 (SD 2.16) with ozonated olive oil. Both oils improved neovascularisation versus contro…

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

PMID 25207143 ↗2013Reported benefit

Effects of ozonated olive oil on acute radiation proctitis in rats.

RatRadiationRectal (topical)1 mL per administrationStarting after irradiation

Model: Acute radiation proctitis induced by a single 17.5 Gy fraction of pelvic irradiation

Five rats in the irradiation plus saline group showed Grade 4 clinical symptoms by day 10, and radiation-induced mucosal damage was most prominent at day 10 in saline-treated animals. Macroscopic finding scores at day 10 differed significantly between the irradiation plus saline and irradiation plu…

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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