Optimization of an injectable tendon hydrogel: the effects of platelet-rich plasma and adipose-derived stem cells on tendon healing in vivo.
RatWoundWistarn = 55 rats across five experimental conditionsLocal injection into the tendon defect50 microlitres saline control; 50 microlitres hydrogel; 45…At the time of defect creation
Model: Full-thickness defect created in the midsubstance of the Achilles tendon
Hydrogel augmented with platelet-rich plasma and/or adipose-derived stem cells increased mean ultimate failure load at week 2 versus hydrogel alone, hydrogel alone caught up by week 4, and at week 8 hydrogel with both platelet-rich plasma and stem cells was stronger than other groups except hydroge…
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