THERAPY DOSSIER · th-938a3ac7fca2

n-butanol extract of Camellia sinensis (green tea)

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02147041 ↗PHASE2/PHASE3unknown

Effect of Extract of Green Tea (EGCG) on Obese Women Hormone Peptides

Diabetes Mellitus · Hyperlipidemia

Enrolment: 92 · Results not recorded

NCT00942422 ↗PHASE2terminated

Polyphenon E (Green Tea Catechin Extract, EGCG) in Plasma Cell Dyscrasias

Multiple Myeloma and Plasma Cell Neoplasm

Enrolment: 8 · Results not recorded

NCT01861171 ↗NAcompleted

Effect of Green Tea on Adiposity, Metabolic Profile, BP and Endothelial Function in Obese Women

Obese · Hypertension

Enrolment: 30 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28294073 ↗2017Reported benefit

Alcohol Induced Hepato Cardiotoxicity and Oxidative Damage in Rats: The Protective Effect of n-butanol Extract of Green Tea (Camellia sinensis (L.) Kuntze).

RatChemical/toxinfemaleoral100 mg/kg body weightfor three days before and simultaneously with ethanol administration

Model: Acute binge ethanol exposure, 40 per cent v/v at 5 g/kg orally every 12 hours for 3 doses

The extract at 100 mg/kg significantly reversed ethanol-induced changes in lipid peroxidation, glutathione, lipid profile and serum aminotransferase activities, indicating protection of heart and liver through attenuation of oxidative stress.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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