THERAPY DOSSIER · th-91d9822e1f18

Larval (maggot) therapy using Cochliomyia macellaria

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02816749 ↗PHASE4unknown

Maggot Debridement Therapy Versus Conventional Dressing Therapy in Type 2 Diabetic Foot Ulcers

Diabetic Foot Ulcers

Enrolment: 138 · Results not recorded

NCT01211236 ↗PHASE3completed

Maggot Therapy for Wound Debridement: Randomised Multicentric Double-blind Trial

Pressure Ulcers

Enrolment: 120 · Results not recorded

NCT02294175 ↗NAcompleted

Larval Debridement Therapy Versus Sharp Debridement to Remove Biofilm From Chronic Lower Extremity or Diabetic Foot Ulcers

Lower Extremity or Diabetic Foot Ulcers

Enrolment: 45 · Results not recorded

NCT01681160 ↗NAcompleted

Maggot Therapy in Diabetic Foot Ulcers

Diabetic Foot Ulcers

Enrolment: 128 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26976407 ↗2016Reported benefit

Evaluation of conventional therapeutic methods versus maggot therapy in the evolution of healing of tegumental injuries in Wistar rats with and without diabetes mellitus.

RatWoundWistarMalen = 24 Wistar rats, 12 with induced type 1 diabetes; four group…Topical application to the wound25 larvae per square centimetre of lesion

Model: Induced tegumental (skin) lesions in animals with and without induced type 1 diabetes mellitus

Larval application removed only dead tissue, was reported safe, and accelerated healing compared with the other treatments.

Extraction: extract · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.

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