THERAPY DOSSIER · th-8ff9c9c14259

Neural stem/progenitor cells combined with treadmill training

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02163876 ↗Injury indicationPHASE2terminated

A Phase II Study of Human Central Nervous System Stem Cells (HuCNS-SC) Transplantation in Cervical Spinal Cord Injury

Cervical Spinal Cord Injury

Enrolment: 31 · Results not recorded

NCT03629275 ↗PHASE2terminated

A Study of Intracerebral Stem Cells (CTX0E03) in Subjects With Disability Following an Ischemic Stroke

Ischemic Stroke · Chronic Stroke

Enrolment: 15 · Results not recorded

NCT05306457 ↗PHASE1active not recruiting

Human Neural Progenitor Cells Secreting GDNF (CNS10-NPC-GDNF) Delivered to the Motor Cortex for ALS

Amyotrophic Lateral Sclerosis

Enrolment: 16 · Results not recorded

NCT01916369 ↗PHASE1completed

A Phase I Ascending Dose Safety Study Of Intramuscular CTX0E03 (Neural Stem Cells) In Patients With Lower Limb Ischaemia

Peripheral Arterial Disease

Enrolment: 5 · Results not recorded

NCT01238315 ↗PHASE1withdrawn

A Phase Ib Study of Allogeneic Intracerebral Human Central Nervous System Stem Cell Transplantation in Neuronal Ceroid Lipofuscinosis

Neuronal Ceroid Lipofuscinosis

Enrolment: 0 · Results not recorded

NCT02055196 ↗PHASE1withdrawn

A Phase I Study of Intracranially Administered Carboxylesterase-Expressing Neural Stem Cells With Irinotecan in Recurrent High-Grade Gliomas

Recurrent Adult Brain Tumor

Enrolment: 0 · Results not recorded

Preclinical evidence 2

1 studies reported at therapy level; 2 evidence entries itemised.

PMID 27485458 ↗2016Reported benefit

Functional Recovery from Neural Stem/Progenitor Cell Transplantation Combined with Treadmill Training in Mice with Chronic Spinal Cord Injury

MouseSpinal cord injuryContusionC57BL/6JFemalen = 70Intraspinal injection49 days after injury (chronic phase)

Model: 70 kdyn contusive spinal cord injury at T9

Combined transplantation and treadmill training improved locomotor score (p=0.035) and gait speed (p=0.026) relative to control, reduced spasticity and promoted neuronal differentiation of grafted cells with synaptic maturation

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

PMID 19893739 ↗2010

Roles of ES cell-derived gliogenic neural stem/progenitor cells in functional recovery after spinal cord injury

MouseSpinal cord injury

Extraction: mesh. Machine-extracted fields require source verification.

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