THERAPY DOSSIER · th-8f50a82b18c6

Nerve lengthening followed by tension-free end-to-end repair (LETER)

Procedure · Surgical procedure: gradual mechanical elongation of the proximal and distal nerve stumps to close a gap, followed by direct tension-free epineurial coaptation, avoiding an autograft and its second suture line. Not a chemical entity, so no ChEMBL record is expected.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Surgical procedure: gradual mechanical elongation of the proximal and distal nerve stumps to close a gap, followed by direct tension-free epineurial coaptation, avoiding an autograft and its second suture line. Not a chemical entity, so no ChEMBL record is expected.
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01116362 ↗Injury indicationPHASE2completed

Study of surgical methods for repair of clean transections in peripheral nerve injuries (primary vs secondary repair)

Peripheral Nerve Injury

Enrolment: 46 · Results not recorded

NCT04327154 ↗Injury indicationNAcompleted

Safety and performance of the TISSIUM nerve coaptation device for digital nerve discontinuities where gap closure is achieved by flexion of the extremity

Digital Nerve Injury

Enrolment: 12 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32333909 ↗2020No effect reported

A comparative assessment of lengthening followed by end-to-end repair and isograft repair of chronically injured peripheral nerves.

RatOtherLewis (Rats, Inbred Lew)SurgicalRepair performed after a long delay following transection (chronic injury)

Model: Chronic peripheral nerve injury: transection of the sciatic nerve with repair performed after a long delay

Structural and functional outcomes after nerve lengthening with end-to-end repair were comparable to isograft repair, with no significant differences in functional recovery or axon growth. Outcomes for chronic injuries were less favourable than for acute injuries in both groups.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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