THERAPY DOSSIER · th-8e63122458e7

Aqueous extract of a marine polychaete worm formulated as a topical ointment in cetomacrogol emulsifying base

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 33488747 ↗2020Reported benefit

Acute Wound Healing Potential of Marine Worm,Grube, 1878 Aqueous Extract on Sprague Dawley Rats.

RatWoundSprague DawleyFemalen = 35 rats in total, 5 per group across seven groups, each rat…TopicalOintment at 0.1%, 0.5% and 1.0% weight per weight; about 30…Treatment started on the day of wounding (day 0)

Model: Paired full-thickness circular excisional skin wounds about 8 mm in diameter created on the dorsum with a disposable biopsy punch

The 1.0% ointment gave the fastest closure, reaching 88.1 plus or minus 1.3% healing at day 7 and 99.8 plus or minus 0.1% at day 14 versus 88.4 plus or minus 0.4% for untreated wounds, significantly faster than acriflavine at days 7 and 11 and comparable to 15% gamat oil, with denser collagen and m…

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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