Radioprotective effect of newly synthesized toll-like receptor 5 agonist, KMRC011, in mice exposed to total-body irradiation
MouseRadiationC57BL/6N for the survival and mechanistic studies; ICR for the cytokine pharmacokinetic studyMalen = Ten C57BL/6N mice per group in the 30-day survival study; n…Intramuscular for the survival and mechanistic studies; intramuscular, intraperitoneal and subcutaneous compared in the pharmacokinetic study0.01 mg/kg or 0.05 mg/kg in the 30-day survival study; 0.05…First dose 15 min after total-body irradiation (post-injury treatment)
Model: Lethal total-body gamma irradiation, 11 Gy cobalt-60 at a dose rate of 0.5 Gy/min under Zoletil/Rompun anaesthesia
KMRC011 given after 11 Gy total-body irradiation improved 30-day survival in a dose- and repetition-dependent manner: 90% survival with four 0.01 mg/kg doses (p = 0.0002), 50% with two doses (p = 0.009), 40% with one dose (p = 0.07) and 70% with a single 0.05 mg/kg dose, versus 10% survival with PB…
Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.