THERAPY DOSSIER · th-8bdd1076063d

Synbiotic preparation (probiotics plus prebiotics)

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 10

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07044310 ↗PHASE2recruiting

Phase 2 Trial of 5-Strain Probiotic Formulation in HR-Positive Breast Cancer Receiving Aromatase Inhibitor to Prevent Bone Loss

Hormone Receptor-Positive Breast Carcinoma

Enrolment: 38 · Results not recorded

NCT06615986 ↗EARLY_PHASE1recruiting

Evaluation of a Human Milk Oligosaccharide-Based Synbiotic Supplement for Intestinal Microbiota Dysbiosis

Healthy Volunteers

Enrolment: 100 · Results not recorded

NCT06169566 ↗NAunknown

Analysis of Gut Microbiome in Thai Women With PCOS and the Synbiotics Effect on Reproductive and Cardiovascular Risk

PCOS- Polycystic Ovary Syndrome

Enrolment: 40 · Results not recorded

NCT06974994 ↗NArecruiting

Resilience to Antibiotic-induced Obesogenic Microbiota Vertically Transferred to the Neonatal Gut

Healthy Newborn Infants

Enrolment: 125 · Results not recorded

NCT07755566 ↗NAcompleted

Open-Label Trial of the Mico HPV Synbiotic Dietary Supplement on Vaginal and Intestinal Microbiota in HPV-Positive Patients

Papillomavirus Infections

Enrolment: 21 · Results not recorded

NCT07411131 ↗NAnot yet recruiting

Pilot Study of a Novel Synbiotic Formula (SGR11) in Patients With Inflammatory Bowel Disease

Inflammatory Bowel Disease · Ulcerative Colitis

Enrolment: 50 · Results not recorded

NCT04776772 ↗NAcompleted

Differential Health Effects on Inflammatory, Immunological and Stress Parameters After Consuming a Synbiotic

Athlete · Sedentary Behavior

Enrolment: 27 · Results not recorded

NCT05073029 ↗NAcompleted

Personalized Nutrition, Physical Activity and Therapy to Modulate Gut Microbiota

Healthy · Obesity · Nutrition · Vitamin D Deficiency

Enrolment: 120 · Results not recorded

NCT07717359 ↗NAnot yet recruiting

Gut-Brain Study: ADHD, Gastrointestinal Problems and Synbiotic Cap

ADHD · Gastrointestinal · Emotion Regulation Abilities

Enrolment: 174 · Results not recorded

NCT02445560 ↗NAcompleted

Effects of a High Protein Diet on Microbiota and the Potential Mitigating Effects of a Multi-strain Probiotic, Prebiotic, and Synbiotic

Aging

Enrolment: 29 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23695868 ↗2013Reported benefit

The effect of synbiotics on acute radiation-induced diarrhea and its association with mucosal inflammatory and adaptive responses in rats.

RatRadiationWistarMalen = 90 adult rats randomly assigned to six groupsSupplementation from the beginning of the experiment

Model: Acute radiation-induced intestinal injury and diarrhoea

Synbiotic supplementation did not prevent diarrhoea but significantly reduced its severity, neutrophil accumulation and lipid peroxidation and improved histology and weight loss.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

Loading the evidence…