THERAPY DOSSIER · th-8b43432c7477

Subventricular zone-derived neural progenitor cells (GFP-labelled neurospheres)

Other

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 8

2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02163876 ↗Injury indicationPHASE2terminated

Phase II Proof-of-Concept Study of Human Central Nervous System Stem Cells (HuCNS-SC) Transplantation in Cervical Spinal Cord Injury

Cervical Spinal Cord Injury · Spine Injury

Enrolment: 31 · Results not recorded

NCT02688049 ↗Injury indicationPHASE1/PHASE2unknown

NeuroRegen Scaffold Combined With Mesenchymal Stem Cells or Neural Stem Cells for Chronic Spinal Cord Injury Repair

Spinal Cord Injury

Enrolment: 30 · Results not recorded

NCT02117635 ↗PHASE2completed

Phase II Efficacy Study of Intracerebral CTX0E03 DP in Patients With Stable Paresis of the Arm Following Ischaemic Stroke

Ischaemic Stroke · Cerebral Infarction · Hemiparesis

Enrolment: 23 · Results not recorded

NCT03629275 ↗PHASE2terminated

Randomized Placebo-Controlled Study of Intracerebral Stem Cells (CTX0E03) in Subjects With Disability Following an Ischemic Stroke

Ischemic Stroke · Chronic Stroke · Hemiparesis

Enrolment: 15 · Results not recorded

NCT04631406 ↗PHASE1/PHASE2active not recruiting

Phase 1/2a Study of Intracerebral Transplantation of Neural Stem Cells (NR1) in Chronic Ischemic Subcortical Stroke

Ischemic Stroke

Enrolment: 27 · Results not recorded

NCT03296618 ↗PHASE1unknown

Phase I Study of Intracerebral Transplantation of Neural Stem Cells (NSI-566) for Ischemic Stroke

Ischemic Motor Stroke, Chronic

Enrolment: 18 · Results not recorded

NCT03725865 ↗EARLY_PHASE1unknown

Intracerebral Transplantation of Human Peripheral Blood Derived Induced Neural Stem Cells for Cerebral Hemorrhagic Stroke

Stroke, Ischemic

Enrolment: 12 · Results not recorded

NCT03005249 ↗NAunknown

Neural Stem Cells Therapy for Cerebral Palsy: Prospective Randomized Parallel-controlled Trial

Cerebral Palsy

Enrolment: 20 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27302679 ↗2016Reported benefit

Intraspinal transplantation of subventricular zone-derived neural progenitor cells improves phrenic motor output after high cervical spinal cord injury.

RatSpinal cord injuryHemisection / partialSprague-Dawley (adult recipients); neonatal EGFP-transgenic Sprague-Dawley SD-Tg(GFP)2BalRrrc donorsFemalen = Cohort 1: 8 NPC transplant, 4 sham transplant, 4 C2Hx only.…Intraspinal injection at C2-3, ventromedial white matter approximately 1 mm caudal to the lesion and 1.5 mm below the dorsal surface, via 10 microlitre Hamilton syringe and 31 gauge needleApproximately 500,000 live cells in 5 microlitres of growth…7 days after C2 hemisection

Model: C2 spinal cord hemisection (C2Hx), high cervical spinal cord injury

Transplantation increased inspiratory tidal volume during hypoxic (P=0.003) and hypercapnic (P=0.019) challenge at 4 and 8 weeks, and increased ipsilateral phrenic burst amplitude across conditions (P<0.001), with no change in contralateral phrenic output, burst frequency or eupneic breathing. Roug…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.

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