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RESEARCH WORKSPACE

Overview Therapies2,752 Studies Translation & outcomes Mechanisms Research gaps Safety findings

Methods & citation

August 2026 datasetResearch window · 1980–2020

A project by Pebble.

PEBBLE / ATLAS

Open research access

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Research linked to primary sources.Privacy CookiesDataset: 25 August 2026

Therapies/Evidence dossier

THERAPY DOSSIER · th-8a17b825c6e7

Hypothermia

Device

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation · TBI · Haemorrhage/shock · Spinal cord injury
Reported indication: Neonatal HIE (standard of care)
First approval: Not recorded
Development stage: Device / non-drug
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 17

17 studies reported at therapy level; 17 evidence entries itemised.

PMID 16967001 ↗2006

Local cooling restores microcirculatory hemodynamics after closed soft-tissue trauma in rats

Rat

Extraction: mesh. Machine-extracted fields require source verification.

PMID 16484924 ↗2006

Whole-body moderate hypothermia confers protection from wood smoke-induced acute lung injury in rats: the therapeutic window

Rat

Extraction: mesh. Machine-extracted fields require source verification.

PMID 16086699 ↗2005

Progenitor cell injury after irradiation to the developing brain can be modulated by mild hypothermia or hyperthermia

RatRadiation

Extraction: mesh. Machine-extracted fields require source verification.

PMID 15000758 ↗2004

The therapeutic efficacy conferred by the 5-HT(1A) receptor agonist 8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) after experimental traumatic brain injury is not mediated by concomitant hypothermia

RatTBI

Extraction: mesh. Machine-extracted fields require source verification.

PMID 12165134 ↗2002

Effects of mild hypothermia and alkalizing agents on brain injuries in rats with acute subdural hematomas

Rat

Extraction: mesh. Machine-extracted fields require source verification.

PMID 12020858 ↗2002

Acute systemic administration of interleukin-10 suppresses the beneficial effects of moderate hypothermia following traumatic brain injury in rats

RatTBI

Extraction: mesh. Machine-extracted fields require source verification.

PMID 19558276 ↗2009

Alterations in blood-brain barrier permeability to large and small molecules and leukocyte accumulation after traumatic brain injury: effects of post-traumatic hypothermia

RatTBI

Extraction: mesh. Machine-extracted fields require source verification.

PMID 18977220 ↗2009

Immediate short-duration hypothermia provides long-term protection in an in vivo model of traumatic axonal injury

Rat

Extraction: mesh. Machine-extracted fields require source verification.

PMID 15959464 ↗2005

Influence of therapeutic hypothermia on matrix metalloproteinase activity after traumatic brain injury in rats

RatTBI

Extraction: mesh. Machine-extracted fields require source verification.

PMID 15922484 ↗2005

The effect of therapeutic hypothermia on the expression of inflammatory response genes following moderate traumatic brain injury in the rat

RatTBI

Extraction: mesh. Machine-extracted fields require source verification.

PMID 12745625 ↗2003

Long term production of reactive oxygen species during perinatal asphyxia in the rat central nervous system: effects of hypothermia

Rat

Extraction: mesh. Machine-extracted fields require source verification.

PMID 10908929 ↗2000

Systemic cooling may protect against the detrimental effects of aggressive spinal surgical procedures

RatHaemorrhage/shock

Extraction: mesh. Machine-extracted fields require source verification.

PMID 10879763 ↗2000

Beneficial effects of modest systemic hypothermia on locomotor function and histopathological damage following contusion-induced spinal cord injury in rats

RatSpinal cord injury

Extraction: mesh. Machine-extracted fields require source verification.

PMID 10757325 ↗2000

Effects of hypothermia on intracranial pressure and brain edema formation: studies in a rat acute subdural hematoma model

Rat

Extraction: mesh. Machine-extracted fields require source verification.

PMID 10724118 ↗2000

Importance of posttraumatic hypothermia and hyperthermia on the inflammatory response after fluid percussion brain injury: biochemical and immunocytochemical studies

RatTBI

Extraction: mesh. Machine-extracted fields require source verification.

PMID 10486200 ↗1999

Moderate posttraumatic hypothermia decreases early calpain-mediated proteolysis and concomitant cytoskeletal compromise in traumatic axonal injury

RatTBI

Extraction: mesh. Machine-extracted fields require source verification.

PMID 20504158 ↗2010

Hypothermia prior to decompression: buying time for treatment of acute spinal cord injury

RatSpinal cord injury

Extraction: mesh. Machine-extracted fields require source verification.

Record at a glance

Study window: 1999–2010
Corpus tranches: 1990-2010
Species: Rat
Physical-trauma evidence: Present
Repurposed: Not flagged
Combination: Not flagged
Withdrawal flag: Not flagged
Dataset: 2026-08-25

Sources & provenance

No primary citation attached yet.

How records are classified