THERAPY DOSSIER · th-8917740aed86

Human embryonic stem cell derived neural stem cells (H9NSCs) engineered for doxycycline-regulatable Tet-off expression of the cell adhesion molecule L1, quantum dot labelled

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04812431 ↗Injury indicationPHASE1/PHASE2recruiting

Phase 1/2a PSA-NCAM(+) neural precursor cells derived from a human embryonic stem cell line in AIS-A sub-acute spinal cord injury

Spinal Cord Injury, Acute · Spinal Cord Injury at C4 Level With Complete Lesion · Spinal Cord Injury at C5-C7 Level With Complete Lesion

Enrolment: 5 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24125017 ↗2014Reported benefit

Analysis of human embryonic stem cells with regulatable expression of the cell adhesion molecule L1 in regeneration after spinal cord injury

MouseSpinal cord injuryCompressionIntraspinal transplantation at three sites, the lesion, proximal and caudal

Model: Acute compression spinal cord injury in immunosuppressed mice

Mice transplanted with L1-on cells achieved better Basso Mouse Scale scores than those receiving L1-off cells, and at 6 weeks post-transplantation showed higher L1 expression, greater migration of transplanted cells and higher tyrosine hydroxylase immunoreactivity together with lower chondroitin su…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

Loading the evidence…