Gastroprotective and cicatrizing activity of the Ziziphus joazeiro Mart. leaf hydroalcoholic extract.
MouseChemical/toxinMale and femalePer os; intraperitoneal for the physical barrier comparison2000 mg/kg for acute toxicity; 100, 200 and 400 mg/kg for g…Administered before induction of gastric lesions
Model: Acute gastric lesions induced by indomethacin, absolute ethanol and acidified ethanol; excisional skin wound closure model
The extract was gastroprotective at 400 mg/kg orally in all three acute gastric injury models, consistent with a physical barrier mechanism, but had no significant effect on wound contraction or closure speed.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.