THERAPY DOSSIER · th-883f4e610f10

Mibefradil dihydrochloride; flunarizine hydrochloride

Drug · Flunarizine: calcium channel blocker/antimigraine; co-tested with mibefradil (T-type Ca channel blocker).

Evidence & regulatory context

Mechanism: Flunarizine: calcium channel blocker/antimigraine; co-tested with mibefradil (T-type Ca channel blocker).
Target: Not recorded
Injury models: Endotoxin/LPS
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL30008 ↗
ChEMBL max phase: 2 / 4 (development scale, not regulatory approval)
Synonyms: Sibelium; mibefradil (co-tested)
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04702971 ↗PHASE4unknown

Decoding Pain Sensitivity in Migraine (Flunarizine)

Migraine

Enrolment: 600 · Results not recorded

NCT06499116 ↗PHASE4not yet recruiting

First-line Preventive Treatment of Migraine incl Flunarizine (PREMI)

Migraine

Enrolment: 460 · Results not recorded

NCT00752466 ↗PHASE1completed

Drug Interaction Study of Flunarizine and Topiramate

Migraine

Enrolment: 75 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 33223955 ↗2020Reported benefit

Mibefradil and Flunarizine, Two T-Type Calcium Channel Inhibitors, Protect Mice against Lipopolysaccharide-Induced Acute Lung Injury.

MouseEndotoxin/LPSBALB/cMaleIntraperitonealMibefradil 20 and 40 mg/kg; flunarizine 30 mg/kg30 minutes before or 30 minutes after LPS exposure

Model: Lipopolysaccharide-induced acute lung injury, aerosolised LPS 0.5 mg/mL (E. coli 055:B5) for 30 minutes in a chamber

Both mibefradil and flunarizine reduced BALF cell influx, total protein, TNF-alpha and IL-6, Evans blue extravasation, myeloperoxidase activity and histological injury, with mibefradil also suppressing NF-kB activation. Post-treatment was effective but less so than pre-treatment for flunarizine.

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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