THERAPY DOSSIER · th-882e9e29aac4

Moderate hypothermia

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00222742 ↗Injury indicationPHASE3terminated

Pediatric Traumatic Brain Injury Consortium: Hypothermia (induced moderate hypothermia)

Traumatic Brain Injury

Enrolment: 90 · Results not recorded

NCT03163589 ↗PHASE3unknown

Effect of Erythropoietin and Hypothermia on Neonatal Hypoxic Ischemic Encephalopathy

Hypoxic-Ischemic Encephalopathy

Enrolment: 40 · Results not recorded

NCT02826941 ↗PHASE2completed

Moderate Hypothermia in Neonatal Hypoxic Ischemic Encephalopathy

Hypoxic Ischemic Encephalopathy

Enrolment: 65 · Results not recorded

NCT05778188 ↗PHASE2recruiting

RLS-0071 in Newborns With Moderate/Severe HIE Undergoing Therapeutic Hypothermia

Hypoxic-Ischemic Encephalopathy

Enrolment: 70 · Results not recorded

NCT03968861 ↗Phase not recordedcompleted

Neurological Outcome Following Xenon Combined With Moderate Hypothermia After Perinatal Asphyxia

Perinatal Asphyxia

Enrolment: 69 · Results not recorded

NCT02754193 ↗NAcompleted

Effects of Induced Moderate Hypothermia on Mortality in Cardiogenic Shock Rescued by VA-ECMO

Cardiogenic Shock

Enrolment: 334 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30236124 ↗2018Reported benefit

Moderate hypothermia inhibits microglial activation after traumatic brain injury by modulating autophagy/apoptosis and the MyD88-dependent TLR4 signaling pathway.

RatTBIFluid percussionSprague-DawleyMalen = 60 rats per group across four groups (240 total), with six…Partial whole-body immersion in an ice-cold water bath under general anaesthesia, with the animal in a plastic bag and head exposedTarget brain temperature 32 degrees C (normothermia control…Started after the fluid percussion injury, with about 30 min needed to reach ta…

Model: Lateral fluid percussion traumatic brain injury, moderate severity 2.1-2.2 atm applied for 10 ms to the exposed dura via a left parietal craniectomy, 24 h after surgical preparation

At 24 h after injury, moderate hypothermia reduced cleaved caspase 3 positive cells (injured cortex 13.3 +/- 1.49 versus 23.2 +/- 2.39) and Iba-1 positive microglia (17 +/- 1.25 versus 22 +/- 1.94), reduced LC3 and Beclin-1 positive microglia, increased cleaved caspase 3 positive microglia (16.9 +/…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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