THERAPY DOSSIER · th-86f0c1e7d990

Tissue adhesives and sealants: TachoSil, GelitaSpon and Adhflex elastic cyanoacrylate

Device · TachoSil is a fibrinogen/thrombin-coated collagen sealant patch (device/biologic); no small-molecule ChEMBL entry

Device Suggest a correction

Evidence & regulatory context

Mechanism: TachoSil is a fibrinogen/thrombin-coated collagen sealant patch (device/biologic); no small-molecule ChEMBL entry
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06124209 ↗PHASE4unknown

Fibrin Sealant Patch (TachoSil) for Vein Anastomosis During Deceased Donor Liver Transplantation

Liver Transplant; Complications

Enrolment: 170 · Results not recorded

NCT03269955 ↗PHASE4unknown

Fibrinogen/Thrombin-coated Collagen Patch (TachoSil) in Pancreaticojejunostomy for Fistula Prevention

Pancreatic Neoplasm

Enrolment: 126 · Results not recorded

NCT04065880 ↗NAcompleted

Neoveil vs TachoSil for Treatment of Pulmonary Air Leaks Following Lung Operation

Prolonged Air Leak

Enrolment: 46 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28650114 ↗2017Mixed findings

The effect of adhesives on inflammatory immune-markers during renal injury healing.

RatOtherWistarMalen = 90 male Wistar rats in total: sham n = 3, untreated n = 6,…Topical application to the renal lacerationApplied at the time of injury

Model: Renal traumatic injury created experimentally with a punch device

All three sealants supported a normal healing process with the typical pattern of proinflammatory cytokine and immune marker expression. TachoSil showed the least inflammatory reaction but the highest cytokine expression, while Adhflex had the highest CD31 levels at 2 and 6 days, with CD31 declinin…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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