THERAPY DOSSIER · th-85fdbfb43d60

Platelet-rich plasma adsorbed on branched poly(ester urea) nanofibre disc

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 7

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04188561 ↗PHASE4completed

Comparative Study Between Intra Articular Injection of Hyaluronic Acid With Platelet Rich Plasma Versus Genicular Nerve Thermal Radiation in Knee Osteoarthritis

Knee Osteoarthritis

Enrolment: 100 · Results not recorded

NCT03293368 ↗PHASE2completed

Efficacy of Intralesional Injection of Autologous Platelet Rich Plasma Versus Corticosteroids on Pain Relief and Ulcer Healing in Erosive Oral Lichen Planus

Erosive Oral Lichen Planus

Enrolment: 20 · Results not recorded

NCT03618979 ↗NAterminated

A Randomized Controlled Trial to Assess the Effects of Autologous Platelet Rich Plasma, Platelet Lysate, and Platelet Poor Plasma on Atrophied Multifidus Muscles in Patients With Axial Lower Back Pain

Low Back Pain

Enrolment: 8 · Results not recorded

NCT06930248 ↗NAnot yet recruiting

Efficacy of Platelet-rich Plasma in Management of Anosmia

Anosmia

Enrolment: 100 · Results not recorded

NCT07551271 ↗NAcompleted

The Application of Platelet-rich Plasma in the Treatment of Androgenic Alopecia

Androgenetic Alopecia

Enrolment: 30 · Results not recorded

NCT02672085 ↗NAunknown

In Vivo Clinical and Radiological Effects of Platelet-rich Plasma on Interstitial Supraspinatus Lesion: Randomized Study

Supraspinatus Interstitial Partial-thickness Tears

Enrolment: 84 · Results not recorded

NCT04937998 ↗NArecruiting

The Use of Fresh PRP vs HA in the Treatment of Osteoarthritis of the Patellofemoral Joint

Patellofemoral Osteoarthritis

Enrolment: 166 · Results not recorded

Preclinical evidence 2

1 studies reported at therapy level; 2 evidence entries itemised.

PMID 29906391 ↗2018Reported benefit

Enhanced Rotator-Cuff Repair Using Platelet-Rich Plasma Adsorbed on Branched Poly(ester urea)s.

RatOtherSprague-DawleyFemaleLocal implantation of a platelet-rich plasma-soaked nanofibre disc at the repair site, or local platelet-rich plasma injectionAt the time of surgical repair

Model: Acute rotator-cuff tear with surgical repair

The platelet-rich plasma-soaked disc group showed the highest stiffness at 84 days (16.8 +/- 5.8 N/mm) compared with suture repair only (13.5 +/- 3.8 N/mm), disc alone (11.8 +/- 3.8 N/mm) and platelet-rich plasma injection (12.2 +/- 2.6 N/mm), with greater collagen organisation at 21 and 84 days an…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

PMID 19282509 ↗2009

Use of autologous platelet-rich plasma to treat muscle strain injuries

RatOther

Extraction: mesh. Machine-extracted fields require source verification.

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