THERAPY DOSSIER · th-85d05ba2a835

Cholecystokinin-octapeptide (CCK-8)

Hormone · AGONIST at cholecystokinin A receptor (CHEMBL1901); direct interaction, disease efficacy true (FDA label ref)

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This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: AGONIST at cholecystokinin A receptor (CHEMBL1901); direct interaction, disease efficacy true (FDA label ref)
Target: CHEMBL1901 (Cholecystokinin A receptor)
Injury models: Endotoxin/LPS
Reported indication: Not recorded
First approval: 1976
Development stage: Not recorded
ChEMBL record: CHEMBL1121 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: CCK-8; CCK-8s; Cholecystokinin c-terminal octapeptide; Kinevac; Sincalide; SQ 19844
Note: Not recorded

Clinical trials 8

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02496221 ↗PHASE4completed

Study Evaluating Effect of Albiglutide on Cholecystokinin-induced Gallbladder Emptying in Fasting Healthy Subjects

Diabetes Mellitus, Type 2

Enrolment: 20 · Results not recorded

NCT00706381 ↗PHASE3completed

Thyroid Hormones Homeostasis and Energy Metabolism Changes During Stimulation of Endogenously Secreted Bile Acids

Healthy Volunteers

Enrolment: 31 · Results posted

NCT04567667 ↗PHASE1completed

Pharmacokinetics and Metabolism of [14C] BMS-986278 in Healthy Male Participants (Kinevac comparator)

Healthy Volunteers

Enrolment: 9 · Results not recorded

NCT02507167 ↗PHASE1completed

Impact of Two Genetic Variants of OATP 1B3 or MRP 2 or Rifampin Mediated Transporter Inhibition on Systemic Disposition and Biological Efficacy of CCK-8

Gastrointestinal Hormones

Enrolment: 19 · Results not recorded

NCT00004414 ↗NAcompleted

Sincalide (Cholecystokinin Octapeptide) Versus Placebo in Neonates at High Risk for Developing Parenteral Nutrition Associated Cholestasis

Cholestasis

Enrolment: 252 · Results not recorded

NCT00685477 ↗NAcompleted

Dose Response of Intravenous Sincalide (CCK-8) for Gallbladder Emptying

Healthy

Enrolment: 60 · Results not recorded

NCT01656057 ↗NAcompleted

The Impact of Gall Bladder Emptying and Bile Acids on the Human GLP-1-secretion

Impact of bile acids on human GLP-1 secretion

Enrolment: 10 · Results not recorded

NCT00737295 ↗NAterminated

Study to Investigate the Role of Ultrasound for Diagnosis of Biliary Dyskinesia (CCK injection)

Biliary Dyskinesia

Enrolment: 25 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27882474 ↗2017Reported benefit

Effects of CCK-8 and Cystathionine gamma-Lyase/Hydrogen Sulfide System on Acute Lung Injury in Rats.

RatEndotoxin/LPS

Model: Lipopolysaccharide-induced acute lung injury

CCK-8 alleviated lipopolysaccharide-induced acute lung injury by regulating cystathionine gamma-lyase catalytic activity and hydrogen sulfide formation.

Extraction: extract · Supplied extraction confidence: 0.4. Machine-extracted fields require source verification.

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