Glucose administration after traumatic brain injury improves cerebral metabolism and reduces secondary neuronal injury.
RatTBIControlled cortical impactSprague DawleyMalen = 77 male rats in total. Experiment 1: Sham-SAL n = 10, Sham-…Intraperitoneal2.0 g/kg as a 50% solution in 0.9% salineExperiment 1: single injection immediately after injury. Experiment 2: injectio…
Model: Unilateral controlled cortical impact: 6 mm craniotomy centred 3 mm posterior to bregma and 3.5 mm left lateral, pneumatic dual-stroke piston with 5 mm flat-tipped impactor at 20 psi and 2.30 to 2.40 m/s, 2 mm depth for 250 ms
A single post-injury glucose dose raised blood glucose from 8.5 to 19.5 mmol/L at 10 min and attenuated the injury-induced depression of cerebral glucose metabolism in 4 of 6 cortical and 2 of 7 subcortical regions, with significantly fewer Fluoro-Jade B positive neurons in cortex (P = 0.05), hilus…
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