Multichannel polymer scaffold seeded with activated Schwann cells and bone mesenchymal stem cells improves axonal regeneration and functional recovery after rat spinal cord injury.
RatSpinal cord injuryComplete transectionSprague-DawleyFemaleAcute intraspinal grafting of the scaffold into the transection gapAcutely, at the time of transection
Model: Complete transection of the thoracic spinal cord with a 3 mm transection gap
From 4 weeks after transplantation onwards, rats receiving scaffolds co-seeded with activated Schwann cells and mesenchymal stem cells showed significantly better BBB scores and electrophysiological recovery. Grafted mesenchymal stem cells survived, differentiated into neuron-like cells and co-loca…
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