THERAPY DOSSIER · th-84624a80ba01

Cucurbita pepo fruit peel methanol extract (CPME)

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07737067 ↗NAcompleted

Cookies Supplemented With Pumpkin (Cucurbita pepo L.) Seeds and Walnuts in Hypercholesterolemia

Hypercholesterolemia · Arthrosclerosis

Enrolment: 25 · Results not recorded

NCT06674005 ↗NAcompleted

Clinical Trial for the Evaluation of Cucurbita pepo Flowers Extract to Promote Skin Health

Skin Laxity · Skin Aging · Skin Wrinkling

Enrolment: 40 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25362619 ↗2014Reported benefit

Protective effect of Cucurbita pepo fruit peel against CCl4 induced neurotoxicity in rat.

RatChemical/toxinSprague-DawleyFemalen = 36 rats in 6 groups of 6200 and 400 mg/kg body weightCo-treatment with CCl4 over the same two-week dosing period

Model: Carbon tetrachloride induced acute neurotoxicity, 20% CCl4 in corn oil at 1 ml/kg body weight intraperitoneally

Co-treatment with Cucurbita pepo fruit peel methanol extract restored brain antioxidant enzyme activities and reduced lipid peroxidation after carbon tetrachloride intoxication in a dose-dependent manner.

Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.

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