Bone marrow-derived mesenchymal stem cells repaired but did not prevent gentamicin-induced acute kidney injury through paracrine effects in rats.
RatChemical/toxinWistarFemalen = n=10 per groupIntravenous1x10^6 cells intravenously or 500 microlitres of conditione…On the 10th day of gentamicin treatment for repair groups, or 24 h before or on…
Model: Gentamicin 40 mg/kg/day intraperitoneally for up to 20 days causing acute kidney injury
Cells, conditioned medium and exosomes reduced creatinine, urea, fractional excretion of sodium, necrosis and apoptosis and increased proliferation, and the effect was abolished by RNase but not trypsin. Prevention starting 24 h before injury was not effective, indicating that injury is needed for…
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