THERAPY DOSSIER · th-80aa7b981f1d

Transplanted exogenous mitochondria derived from PC12 cell culture or from syngeneic leg muscle

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06017869 ↗PHASE2recruiting

Phase II Open Label Single Dose Study of MNV-201 for the Treatment of Pearson Syndrome

Mitochondrial Diseases · Pearson Syndrome

Enrolment: 6 · Results not recorded

NCT05669144 ↗PHASE1/PHASE2unknown

Co-transplantation of MSC-Derived Exosomes and Autologous Mitochondria for Patients Candidate for CABG Surgery With EF<25%

Myocardial Infarction · Myocardial Ischemia · Myocardial Stunning

Enrolment: 20 · Results not recorded

NCT03384420 ↗PHASE1/PHASE2completed

Phase I/II Study of Transplantation of MNV-BM-BLD (Autologous CD34+ Cells Enriched With Blood Derived Mitochondria) in Pediatric Patients With Pearson Syndrome

Mitochondrial Diseases · Pearson Syndrome

Enrolment: 7 · Results not recorded

NCT04998357 ↗NArecruiting

Autologous Mitochondrial Transplant for Cerebral Ischemia

Cerebral Ischemia

Enrolment: 20 · Results not recorded

NCT02851758 ↗NArecruiting

Transplantation of Autologously Derived Mitochondria for Protection Against Ischemia-reperfusion Injury Following Ischemia in Subjects on ECMO Support

Extracorporeal Membrane Oxygenation Complication

Enrolment: 16 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29648982 ↗2018Mixed findings

Effects of Mitochondrial Transplantation on Bioenergetics, Cellular Incorporation, and Functional Recovery after Spinal Cord Injury.

RatSpinal cord injuryContusionSprague-DawleyFemaleInjection into the injured spinal cord

Model: L1/L2 contusion spinal cord injury in rats

Mitochondrial transplantation maintained acute bioenergetics of the injured spinal cord in a concentration-dependent manner, and labelled mitochondria were incorporated into multiple resident cell types although not into neurons. Despite this, transplantation did not improve tissue sparing or long-…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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