PCC7942 secretes extracellular vesicles to accelerate cutaneous wound healing by promoting angiogenesis.
MouseBurnContact / flameC57BL/6Femalen = n = 5 per group for wound healing experiments; n = 3 per gr…Subcutaneous injection at 4 peri-wound sites (25 uL per site)PCC 7942 cell suspension in 100 uL PBS (cell number reporte…First treatment immediately after wounding (day 0)
Model: Full-thickness contact burn: metal rod (25 g, 1 cm diameter) heated to 95-100 C in boiling water, applied vertically for 6 seconds to shaved upper back skin; two burn wounds per mouse; wounds left undressed
Both live PCC 7942 and its extracellular vesicles accelerated burn wound closure, increased re-epithelialisation, reduced scar width and increased Ki67-positive cells and CD31-positive vessels relative to PBS, with comparable effects under light and dark conditions; IL-6 was the only cytokine signi…
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