THERAPY DOSSIER · th-7c252870845a

Low-intensity intrasound therapy (LITR), high-intensity intrasound therapy (HITR) and low-intensity pulsed ultrasound (LIPUS)

Device · Device (intrasound / ultrasound therapy); no matching trial identified for intrasound therapy specifically

Evidence & regulatory context

Mechanism: Device (intrasound / ultrasound therapy); no matching trial identified for intrasound therapy specifically
Target: Not recorded
Injury models: Crush
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22574701 ↗2012Reported benefit

The morphology of the healing tendon: a comparison of the effects of intrasound therapy and therapeutic pulsed ultrasound.

RatCrushLimb / muscle crushSprague-Dawley albinoMalen = 45 male rats randomised into five groups, subdivided into s…Topical application over the injured Achilles tendonTreatment commenced 24 h post-injury and continued over the first 14 days

Model: Induced crush injury to the Achilles tendon

LITR and HITR twice daily significantly increased tenoblast proliferation in the proliferative phase and enhanced terminal differentiation to tenocytes in the remodelling phase compared with untreated and LIPUS-treated groups (p < 0.05), and increased the volume fraction of collagen fibres compared…

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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