Tocilizumab in the Treatment of Idiopathic Retroperitoneal Fibrosis
Idiopathic Retroperitoneal Fibrosis
Enrolment: 40 · Results not recorded
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Biologic
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Idiopathic Retroperitoneal Fibrosis
Enrolment: 40 · Results not recorded
High-risk Smoldering Multiple Myeloma
Enrolment: 85 · Results not recorded
Multiple Myeloma
Enrolment: 53 · Results not recorded
Rheumatoid Arthritis
Enrolment: 181 · Results not recorded
Systemic Lupus Erythematosus
Enrolment: 23 · Results not recorded
End Stage Kidney Disease
Enrolment: 24 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Dextran sodium sulfate (DSS) induced colitis, acute (1.5-3% DSS in drinking water for 5 days followed by 5 days water) and chronic (four cycles of 1.5%, 1.0%, 1.25% and 1.5% DSS)
IL-6 monoclonal antibody treatment produced a small but statistically significant improvement on day 10 only, with body weight 97% of baseline versus 92% in controls and clinical score 1 versus 3. Global Il-6r-deficient and myeloid-specific LysMCre/Il-6r-deficient mice were indistinguishable from c…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.