THERAPY DOSSIER · th-7bcf4f31d40c

Functional electrical stimulation of hindlimb muscles

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

4 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01236976 ↗Injury indicationPHASE3completed

SCIPA Full-On: intensive exercise programme after spinal cord injury (includes FES-assisted cycling)

Spinal Cord Injury

Enrolment: 116 · Results not recorded

NCT00656149 ↗Injury indicationPHASE2/PHASE3completed

Outcome evaluation of exercise and electrical therapy for quadriplegic hand function

Spinal Cord Injury · Quadriplegia · Tetraplegia

Enrolment: 13 · Results not recorded

NCT07164846 ↗Injury indicationNArecruiting

Effect of Neuro20 functional electrical stimulation suit on autonomic function, muscle performance and gait

Spinal Cord Injury · Stroke · Amputees

Enrolment: 30 · Results not recorded

NCT07583576 ↗Injury indicationNAnot yet recruiting

Effects of functional electrical stimulation on spasticity, quadriceps strength and functional mobility in paraplegia

Spinal Cord Injury · Paraplegia · Spasticity

Enrolment: 40 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24090649 ↗2013Reported benefit

Functional electrical stimulation post-spinal cord injury improves locomotion and increases afferent input into the central nervous system in rats.

RatSpinal cord injuryUnspecifiedSprague-DawleyFemaleImplanted intramuscular stimulating electrodes in hindlimb musclesAcute phase after spinal cord injury, with assessment at day 7 post-injury

Model: Spinal cord injury in rats with chronic functional electrical stimulation electrodes implanted in hindlimb muscles

Functional electrical stimulation improved locomotor recovery at day 7 (BBB 10 plus or minus 2 versus 3 plus or minus 1 in controls, P less than 0.05) and significantly increased neurovascular activation in spinal cord and somatosensory cortex.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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