THERAPY DOSSIER · th-79df3b0c1a9d

Purified human bone marrow-derived mesenchymal stem cells delivered in fibrin glue

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01803347 ↗PHASE3completed

Autologous Adipose-Derived Mesenchymal Stem Cells Plus Fibrin Glue for Complex Perianal Fistulizing Disease Without IBD

Anal Fistula

Enrolment: 80 · Results not recorded

NCT02298023 ↗PHASE2completed

Treatment of Tendon Injury Using Allogenic Adipose-derived Mesenchymal Stem Cells in Fibrin Glue: Phase II RCT

Rotator Cuff Tear

Enrolment: 24 · Results not recorded

NCT03449082 ↗PHASE2completed

Treatment of Intractable Common Extensor Tendon Injury Using Allogeneic Adipose-derived Mesenchymal Stem Cells With Fibrin Glue: Phase II RCT

Lateral Epicondylitis

Enrolment: 30 · Results not recorded

NCT02449005 ↗PHASE1/PHASE2completed

Phase I/II RCT of Regenerative Treatment of Infrabony Periodontal Defects Using Autologous Alveolar Bone-Marrow Mesenchymal Stem Cells (BM-MSCs/fibrin glue/collagen fleece)

Chronic Periodontitis

Enrolment: 30 · Results not recorded

NCT05553132 ↗PHASE1active not recruiting

Hip RECLAIM: Phase I Trial of Chondrons Coimplanted With Allogeneic Adipose-Derived Mesenchymal Stromal Cells in a Fibrin Glue Carrier for Focal Hip Cartilage Defects

Cartilage Defect

Enrolment: 15 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27282111 ↗2016Mixed findings

The Effect of Purified Human Bone Marrow-Derived Mesenchymal Stem Cells on Rotator Cuff Tendon Healing in an Athymic Rat.

RatOtherAthymic nude ratn = 52 athymic rats total; per timepoint 10 per group for biome…Local application at the tendon repair site in fibrin glueAt the time of surgical repair

Model: Unilateral detachment and transosseous repair of the supraspinatus tendon (acute small to medium rotator cuff tear and repair)

At 2 weeks human mesenchymal stem cells increased fibrocartilage formation (18.6 +/- 2.9% vs 9.1 +/- 1.6%, P = .026), improved collagen organisation (energy 36.88 +/- 4.99 J vs 54.97 +/- 8.33 J, P = .04; coherence 26.96 +/- 15.32% vs 14.53 +/- 4.10%, P = .05), and raised failure load (11.5 +/- 2.4…

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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