Fibrinogen-loaded polycaprolactone/silk fibroin core-shell nanofiber scaffold forming a fibrin sealant in situ with thrombin

Large-Scale Fabrication of Robust Artificial Skins from a Biodegradable Sealant-Loaded Nanofiber Scaffold to Skin Tissue via Microfluidic Blow-Spinning.

Model: Acute tissue damage models including vascular bleeding, hepatic haemorrhage, large-area abdominal wall defect and cutaneous wound

Microfluidic blow-spinning produced a large-area nanofiber scaffold of fibrinogen-loaded polycaprolactone/silk fibroin core-shell fibres with a mean diameter of 65 nm. In vivo the sealant-loaded scaffold rapidly repaired acute tissue damage including vascular bleeding and hepatic haemorrhage, and p…

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