THERAPY DOSSIER · th-7987d439e249

Electrospun polycaprolactone fibre implant coated with a chitosan-polycaprolactone graft copolymer (CS-g-PCL)

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31670896 ↗2019Mixed findings

Possibilities and limitations of electrospun chitosan-coated polycaprolactone grafts for rotator cuff tear repair.

RatOtherLewisMalen = 51 rats in total, 17 per group (3 groups); 12 per group for…Surgical implantation at the repaired infraspinatus enthesis together with suture fixationAt the second (repair) surgery, 4 weeks after tendon detachment

Model: Chronic rotator cuff tear model: left infraspinatus tendon detached, followed 4 weeks later by repair surgery

Biomechanical parameters did not differ significantly between the CS-g-PCL and polyurethane implant groups, and median force at failure in both implant groups was lower than in the suture-fixed group. Histologically the CS-g-PCL implant showed no acute inflammation, good cell infiltration, ingrowth…

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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