THERAPY DOSSIER · th-78332fb01c17

Freshly isolated human umbilical cord blood CD34+ progenitor cells

Biologic · Cell therapy (umbilical cord blood CD34+ progenitor cells); not a ChEMBL entity

Evidence & regulatory context

Mechanism: Cell therapy (umbilical cord blood CD34+ progenitor cells); not a ChEMBL entity
Target: Not recorded
Injury models: Endotoxin/LPS
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01682226 ↗PHASE2completed

Unrelated Donor Cord Blood Transplantation With CD34+ Cells for High-Risk Hematological Malignancies

Leukemia · Lymphoma

Enrolment: 84 · Results not recorded

NCT03913026 ↗PHASE2active not recruiting

ECT-001-expanded Cord Blood Transplantation in High-risk Acute Leukemia/Myelodysplasia

Hematologic Malignancy

Enrolment: 30 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24558433 ↗2014Reported benefit

Human CD34+ progenitor cells freshly isolated from umbilical cord blood attenuate inflammatory lung injury following LPS challenge.

MouseEndotoxin/LPSNOD.CB17-Prkdc scid (SCID)Malen = n=4 per group for permeability, myeloperoxidase, neutrophil…Retro-orbital intravenous injection0.2 x 10^6 cells per mouse in 150 microlitres3 hours after lipopolysaccharide challenge

Model: Lipopolysaccharide (Escherichia coli O111:B4) 5 mg/kg body weight by intraperitoneal injection; the survival study used a lethal dose of 11 mg/kg

CD34+ cells reduced lung vascular permeability, myeloperoxidase activity, neutrophil infiltration and pro-inflammatory gene expression, increased endothelial proliferation and improved survival, with 40 per cent surviving at least one week whereas all phosphate-buffered saline and CD34-negative tre…

Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.

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