Whole blood vs fractionated blood products for coagulopathy in acute traumatic haemorrhage
Trauma · Acute Hemorrhage · Coagulopathy
Enrolment: 200 · Results not recorded
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Procedure · ChEMBL NOT QUERIED: resuscitation strategy comparing a crystalloid with blood products, no discrete ChEMBL entity; resolved=false by entity class. 174 raw hits for whole blood or Lactated Ringer resuscitation in trauma/haemorrhagic shock, 6 recorded. NCT04431999 and NCT02926274 are the closest human counterparts (whole blood in traumatic haemorrhage). IMPORTANT GAP: no recorded trial compares FRESH whole blood against whole blood STORED 7 DAYS AT 4 degrees Celsius, so the specific storage-duration comparison of the shard study is NOT represented in humans.
6 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Trauma · Acute Hemorrhage · Coagulopathy
Enrolment: 200 · Results not recorded
Hemorrhagic Shock
Enrolment: 71 · Results not recorded
Burn Shock
Enrolment: 240 · Results not recorded
Traumatic Brain Injury
Enrolment: 44 · Results not recorded
Trauma · Hemorrhage · Coagulopathy
Enrolment: 330 · Results not recorded
Wounds and Injuries · Fluid Therapy
Enrolment: 250 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Polytrauma with haemorrhage in anaesthetised rats
Polytrauma and haemorrhage without resuscitation increased lung leukocytes, platelets, myeloperoxidase and both pro- and anti-inflammatory cytokines and chemokines. Resuscitation with Lactated Ringer, fresh whole blood or stored whole blood all raised the lung wet to dry ratio to a similar extent,…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.