Topical application of Cleome viscosa increases the expression of basic fibroblast growth factor and type III collagen in rat cutaneous wound.
MixedWoundWistarn = 20 rats per group across four groupsTopical2.5% w/w hydrogelTreatment started on the day of wounding
Model: Circular 20 mm diameter excision wound created on shaved dorsal skin to the depth of loose subcutaneous tissue under anaesthesia
Extract-treated wounds contracted 60.99, 71.13, 82.34 and 90.87% at days 12, 15, 18 and 21 versus 23.85 to 50.63% in untreated controls, with hydroxyproline 3.947 mg per 100 mg tissue and significant upregulation of COL3A1, bFGF and Smad-2, Smad-3 and Smad-4.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.