Novel Treatment for Diastolic Heart Failure in Women
Heart Failure
Enrolment: 48 · Results not recorded
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Drug · Mineralocorticoid receptor antagonist (ANTAGONIST; direct interaction; disease efficacy true)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Heart Failure
Enrolment: 48 · Results not recorded
Cirrhosis · Portal Hypertension
Enrolment: 96 · Results not recorded
Acne
Enrolment: 350 · Results not recorded
Cardiac Surgery · Atrial Fibrillation · Aldosterone Blockade
Enrolment: 1500 · Results not recorded
Arrhythmogenic Right Ventricular Dysplasia
Enrolment: 120 · Results not recorded
Polycystic Ovary Syndrome
Enrolment: 90 · Results not recorded
Hyperandrogenism · Polycystic Ovary Syndrome · Puberty
Enrolment: 32 · Results not recorded
Heart Failure Congenital
Enrolment: 200 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Acute skeletal muscle injury by intramuscular injection of 50 microlitres of sterile 1.2% barium chloride into the middle portion of the left tibialis anterior; the right tibialis anterior received 50 microlitres of sterile saline as a contralateral control
CYP11B2 aldosterone synthase was localised in CD11b positive infiltrating myeloid cells of normal skeletal muscle after acute injury, peaking at 4 days. Both the conditional knockout and spironolactone increased the number of IgG-positive damaged myofibers at 4 days post-injury, interpreted as stab…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.