THERAPY DOSSIER · th-732492457ae5

Remote ischaemic preconditioning and postconditioning

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02381522 ↗NAcompleted

Remote Ischemic Pre-conditioning in Subarachnoid Hemorrhage

Brain Aneurysms

Enrolment: 26 · Results not recorded

NCT07270887 ↗Phase not recordedrecruiting

Long-term Effect of Remote Ischemic Conditioning on Main Organs in ASCVD Patients (RICMO-ASCVD)

ASCVD

Enrolment: 2800 · Results not recorded

NCT07179887 ↗NArecruiting

Remote Ischaemic Conditioning in the Older Person and Cerebral Autoregulation

Cerebral Autoregulation

Enrolment: 45 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26990366 ↗2016Reported benefit

Remote ischemic conditioning protects against acetaminophen-induced acute liver injury in mice.

MouseChemical/toxinn = n = 6 per group across seven groupsRemote ischaemic conditioningPreconditioning before and postconditioning after acetaminophen administration

Model: Acetaminophen overdose-induced acute liver injury

Both preconditioning and postconditioning significantly lowered transaminases, pro-inflammatory cytokines and oxidative markers and raised antioxidant enzyme activity and haem oxygenase-1; zinc protoporphyrin abolished the protection.

Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.

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