Gastroprotective effects of Leejung-tang, an oriental traditional herbal formula, on ethanol-induced acute gastric injury in rats.
RatChemical/toxinSprague-DawleyMaleOral400 mg/kg body weight2 hours before absolute ethanol administration
Model: Acute gastric mucosal injury induced by oral gavage of absolute ethanol at 5 mL/kg body weight
Leejung-tang protected the gastric mucosa against ethanol-induced injury including haemorrhage and hyperaemia, reduced the rise in lipid peroxidation, and increased glutathione content and antioxidant enzyme activities.
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