Fluid supplementation accelerates epithelial repair during chemical colitis.
MouseChemical/toxinC57Bl/6femalen = n = 16-17 per group until day 7 and n = 9 per group from da…intraperitoneal injection1 mL of 0.9% NaCl per injection (approximately 40 mL/kg)days 3 to 6 after initiation of dextran sulfate sodium administration
Model: Dextran sulfate sodium (3% DSS in drinking water for 6 days) chemical colitis
Fluid supplementation significantly improved body weight loss from days 9 to 12 and reduced disease activity index at the peak of colitis, and accelerated epithelial repair (hyperproliferative mucosa 27.5% versus 7.4% at day 7; normal crypts 56.7% versus 27.9% at day 12; goblet cells 46.7 versus 34…
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