THERAPY DOSSIER · th-71ab0687eef7

Gelatin coating of the inserted needle

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29037893 ↗2017Reported benefit

Gelatin promotes rapid restoration of the blood brain barrier after acute brain injury.

RatTBIPenetrating / ballisticSprague-DawleyFemaleLocal (coating on the inserted needle)At the moment of injury (coated needle insertion)

Model: Transient insertion of stainless steel needles into cortex cerebri (stab wound mimicking neural implant injury)

Gelatin-coated needle injuries showed significantly faster resolution of post-stab bleeding and BBB leakage, differential microglial responses and later increases in MMP-2 and MMP-9, with neurons and astrocytes largely unaffected

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

Loading the evidence…