Neuron and microglia/macrophage-derived FGF10 activate neuronal FGFR2/PI3K/Akt signaling and inhibit microglia/macrophages TLR4/NF-kB-dependent neuroinflammation to improve functional recovery after spinal cord injury.
RatSpinal cord injuryCompressionSprague-DawleyIntravenous1 mg/kg per day; the pathway-inhibitor arm added LY294002 a…Started after surgery; exact interval not stated
Model: T9 laminectomy followed by vascular clip compression at 30 g force for 1 minute, producing a moderate crush injury; anaesthesia with 10% chloral hydrate 3.6 mL/kg intraperitoneally
Daily intravenous FGF10 at 1 mg/kg improved BBB and inclined plane scores from day 14 onward, reduced lesion cavity, motor neuron loss and apoptosis, and attenuated microglial and macrophage activation and pro-inflammatory cytokine release. Benefits were partially reversed by the PI3K inhibitor LY2…
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