THERAPY DOSSIER · th-70eb2bec9ec4

PASylated interferon lambda (PASylated IL-28A, XL-protein GmbH)

Biologic · PASylated interferon lambda (IL-28A); half-life-extended type III interferon cytokine biologic (the interferon-lambda class has reached clinical trials as peginterferon lambda).

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: PASylated interferon lambda (IL-28A); half-life-extended type III interferon cytokine biologic (the interferon-lambda class has reached clinical trials as peginterferon lambda).
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01309932 ↗PHASE2completed

Pegylated Interferon Lambda (BMS-914143) + Ribavirin/DAAs in Chronic Hepatitis C Genotype-1

Hepatitis C

Enrolment: 165 · Results not recorded

NCT00565539 ↗PHASE1completed

PEG-rIL-29 (Interferon Lambda) +/- Ribavirin in Chronic Hepatitis C

Hepatitis C, Chronic

Enrolment: 56 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30503785 ↗2018No effect reported

Regeneration After Radiation- and Immune-Mediated Tissue Injury Is Not Enhanced by Type III Interferon Signaling.

MouseRadiationWild-type and IL-28 receptor alpha subunit-deficient (IL-28Ra) mice, cohoused

Model: Myeloablative total body irradiation causing thymic damage, and allogeneic haematopoietic stem cell transplantation after myeloablative total body irradiation causing graft-versus-host disease

Graft-versus-host disease course was comparable between IL-28Ra-deficient and wild-type mice, and PASylated IL-28A did not significantly modulate graft-versus-host disease or thymic regeneration after irradiation.

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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