THERAPY DOSSIER · th-704c86375a81

Human glial restricted progenitor cells suspended in PureCol matrix

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02478450 ↗PHASE1/PHASE2not yet recruiting

Phase 1/2a Study of Transplantation of Human Glial Restricted Progenitor Cells (Q-Cells) in ALS (ALTA-BOLT)

Amyotrophic Lateral Sclerosis

Enrolment: 30 · Results not recorded

NCT03887273 ↗PHASE1/PHASE2recruiting

Phase 1/2a Study of Transplantation of Human Glial Restricted Progenitor Cells (Q-Cells) in Transverse Myelitis

Transverse Myelitis

Enrolment: 9 · Results not recorded

NCT06163508 ↗Phase not recordedenrolling by invitation

Long Term Follow-Up Study for Subjects Who Received Human Glial Restricted Progenitor Cells (hGRPs; Q-Cells)

Transverse Myelitis

Enrolment: 9 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29408659 ↗2018Mixed findings

Axonal regeneration of different tracts following transplants of human glial restricted progenitors into the injured spinal cord in rats.

RatSpinal cord injuryHemisection / partialSprague-DawleyFemalen = Hemisection 12 rats (8 transplant, 4 control); dorsal colum…Intraspinal injection into the lesion site5 microlitres of cell suspension into the hemisection and 3…Acute, immediately after the lesion was made

Model: Acute cervical C4 spinal cord injury, either dorsal column lesion or lateral hemisection

Grafts increased sensory, raphespinal and reticulospinal axon growth into the lesion but had no effect on coeruleospinal or rubrospinal axons, and no axons grew through the graft.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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