The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation.
MouseChemical/toxinAlbino Swissmaletopical application to the earbucladesine cream 0.5% or 1.5%, 10 +/- 1 mg cream per ear;…3 h before arachidonic acid challenge for the creams and 60 min before challeng…
Model: arachidonic acid induced acute ear oedema, 20 microlitres of 5% arachidonic acid in acetone applied to the left ear with acetone alone to the right ear
The 1.5% cream reduced ear swelling by 28% after a single application and 24% after two applications, while the 0.5% cream and the 5% solution did not reach significance. Ketoprofen 2.5% gel nearly abolished swelling.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.