THERAPY DOSSIER · th-6faf0e4998b5

Bone marrow-derived adherent stromal cells (BMSCT)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: BM-MSC; bone marrow-derived mesenchymal stromal cells; BMSCT
Note: Not recorded

Clinical trials 10

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04435249 ↗PHASE1/PHASE2withdrawn

Autologous BM-MSC Seeded on Decellularised Airway Scaffold in Bronchopleural Fistula

Bronchopleural Fistula

Enrolment: 0 · Results not recorded

NCT02585622 ↗PHASE1/PHASE2terminated

Novel Stromal Cell Therapy for Diabetic Kidney Disease (NEPHSTROM Study)

Diabetic Kidney Disease

Enrolment: 29 · Results not recorded

NCT02150551 ↗PHASE1completed

Safety and Tolerability Of Allogeneic Mesenchymal Stromal Cells in Pediatric Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Enrolment: 1 · Results not recorded

NCT02195323 ↗PHASE1completed

Administration of Autologous Bone Marrow Mesenchymal Stem Cells in Patients With Chronic Kidney Disease

Chronic Kidney Disease

Enrolment: 7 · Results not recorded

NCT02646007 ↗PHASE1unknown

Autologous BM-MSC Transplantation for Avascular Necrosis of the Lunate Bone (Kienbock's Disease)

Kienbock's Disease

Enrolment: 30 · Results not recorded

NCT04328714 ↗PHASE1terminated

Interferon-gamma-Primed Mesenchymal Stromal Cells as Prophylaxis for Acute GvHD After Allogeneic HCT

Acute Leukemia · Myelodysplastic Syndromes

Enrolment: 4 · Results not recorded

NCT02260375 ↗PHASE1unknown

Third-party Bone Marrow-derived Mesenchymal Stromal Cells to Induce Tolerance in Liver Transplant Recipients

Liver Transplant Rejection

Enrolment: 20 · Results not recorded

NCT02387151 ↗PHASE1completed

Safety of Allogeneic Bone Marrow Derived Mesenchymal Stromal Cell Therapy in Renal Transplant Recipients

Rejection · Graft Loss

Enrolment: 10 · Results not recorded

NCT01686139 ↗PHASE1unknown

Treatment of Patients With Diabetic Foot Complications With Allogeneic Bone Marrow Derived Mesenchymal Stromal Cells

Diabetes Mellitus With Ulcer

Enrolment: 12 · Results not recorded

NCT01038596 ↗Phase not recordedcompleted

Proliferation and Osteogenic Differentiation of BM-MSC From Osteoarthritic Versus Healthy Donors

Osteoarthritis

Enrolment: 30 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 21935373 ↗2011Reported benefit

Bone marrow stromal cell transplantation mitigates radiation-induced gastrointestinal syndrome in mice.

MouseRadiationC57BL/6MaleIntravenous24 and 72 h after irradiation

Model: Whole body (10.4 Gy) or abdominal (16-20 Gy) irradiation

Bone marrow stromal cell transplantation rescued mice from radiation gastrointestinal syndrome with 100% survival and restored intestinal stem cell niche.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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