Traumatic brain injury causes selective, CD74-dependent peripheral lymphocyte activation that exacerbates neurodegeneration.
MouseTBIFluid percussionC57BL/6J wild type; CD74 (invariant chain) deficient on C57BL/6 backgroundMalen = 24 h flow cytometry and multiplex: sham plus vehicle n=6, s…Intraperitoneal1 mg/kg (CAP dissolved at 5 mg/mL in DMSO, 5 microL diluted…20 minutes after fluid percussion injury
Model: Lateral fluid percussion injury through a 2 mm craniotomy over the left parietal cortex with dura intact, 12 to 16 ms pulse at approximately 1.4 to 1.6 atm
CAP given 20 minutes after fluid percussion injury reversed the injury-induced expansion of splenic lymphocyte subsets, lowered brain cytokine levels and reduced lesion size and neurodegeneration, with CD74-deficient mice showing similar protection.
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