THERAPY DOSSIER · th-6df8c63c8fd9

Injectable human tendon extracellular matrix hydrogel

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24341855 ↗2014Outcome unclear

Design and characterization of an injectable tendon hydrogel: a novel scaffold for guided tissue regeneration in the musculoskeletal system.

RatOtherWistarPercutaneous injection into the zone of tendon injury

Model: Tendon defect in a rat model, with the extracellular matrix solution delivered percutaneously into the zone of tendon injury; the specific injury procedure is not described in the retrieved sources

The study was principally a characterisation, showing storage and loss moduli of 213.1 plus or minus 19.9 Pa and 27.1 plus or minus 2.4 Pa at 1 rad/s, sigmoidal gelation after about 15 minutes at 37 degrees Celsius, early CD68 positive macrophage invasion followed by increasing fibroblast numbers i…

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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