Phase 2a IV MTP-131 on Reperfusion Injury in Primary PCI for STEMI
Reperfusion Injury · STEMI
Enrolment: 300 · Results not recorded
Loading the evidence…
Biologic · No ChEMBL mechanism_of_action record. Cell-permeable cardiolipin-binding tetrapeptide (molecule_type Protein, max_phase 3) developed by Stealth BioTherapeutics as a mitochondria-targeted agent; ChEMBL exposes no MoA target row, so moa_list is empty.
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Reperfusion Injury · STEMI
Enrolment: 300 · Results not recorded
Renal Artery Obstruction · Hypertension, Renovascular · Ischemia Reperfusion Injury
Enrolment: 16 · Results not recorded
Barth Syndrome
Enrolment: 48 · Results not recorded
Primary Mitochondrial Myopathy
Enrolment: 218 · Results not recorded
Age Related Macular Degeneration
Enrolment: 313 · Results not recorded
Mitochondrial Myopathies · Mitochondrial Diseases
Enrolment: 102 · Results not recorded
Primary Mitochondrial Disease
Enrolment: 30 · Results not recorded
Leber's Hereditary Optic Neuropathy
Enrolment: 12 · Results not recorded
Heart Failure
Enrolment: 308 · Results not recorded
Heart Failure
Enrolment: 71 · Results not recorded
Skeletal Muscle Mitochondrial Dysfunction in the Elderly
Enrolment: 41 · Results not recorded
Age-Related Macular Degeneration
Enrolment: 40 · Results not recorded
Congestive Heart Failure
Enrolment: 36 · Results not recorded
Healthy
Enrolment: 30 · Results not recorded
Healthy Volunteers
Enrolment: 30 · Results not recorded
Mitochondrial Diseases · Barth Syndrome
Enrolment not recorded · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Thermal (burn) injury inducing insulin resistance
SS31 but not the inactive analogue SS20 ameliorated burn-induced insulin resistance in mice.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Sonication-induced traumatic optic neuropathy of the left optic nerve
Intravitreal MTP-131 with subcutaneous etanercept and MTP-131 increased retinal ganglion cell survival by 21 per cent versus PBS controls, with no synergy between etanercept and MTP-131.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.