THERAPY DOSSIER · th-6cbd81979b8f

Fluid resuscitation

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Burn
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 8

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05054270 ↗Injury indicationNAcompleted

Efficacy of lung ultrasound in monitoring fluid resuscitation in trauma patients

Contusions Pulmonary · Lung Injury · Chest Trauma

Enrolment: 100 · Results not recorded

NCT02160548 ↗PHASE3completed

Effect of adding nebulised salbutamol to intravenous atropine and oxygen during resuscitation of organophosphate poisoned patients

Organophosphate Poisoning

Enrolment: 75 · Results not recorded

NCT02654782 ↗PHASE2terminated

Lactated Ringer's versus 5% human albumin: double-blinded randomised prospective study in cardiac surgical patients

Hemodynamic Stability

Enrolment: 10 · Results not recorded

NCT03020407 ↗NAcompleted

Randomised controlled trial of inferior vena cava ultrasound-guided fluid management in septic shock resuscitation

Septic Shock

Enrolment: 211 · Results not recorded

NCT01309724 ↗NAcompleted

Haemodynamic optimisation by non-invasive determination of cardiac output in critically ill patients: randomised controlled trial

Hypotension

Enrolment: 92 · Results not recorded

NCT01945983 ↗NAcompleted

Comparison between early norepinephrine use and standard treatment during severe sepsis and septic shock resuscitation

Septic Shock · Severe Sepsis

Enrolment: 310 · Results not recorded

NCT04180553 ↗NAunknown

Ultrasound-guided resuscitation in open aortic surgery

Aortic Diseases

Enrolment: 40 · Results not recorded

NCT02977429 ↗NAunknown

Central venous-to-arterial carbon dioxide difference in evaluation of fluid therapy for postoperative abdominal cancer patients

Abdominal Tumor · Abdominal Infection

Enrolment: 150 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 2624691 ↗1989Reported benefit

Acute gastric mucosal lesions, haemodynamic and microcirculatory changes in the thermally injured rat.

RatBurnScaldMaleAfter burn injury

Model: Standardised thermal skin (scald) burn injury

Without resuscitation cardiac output fell by 78 per cent with marked reductions in gastric, pancreatic, splenic, muscle, skin and renal blood flow and gross gastric mucosal lesions. With fluid resuscitation cardiac output fell by only 38 per cent, gastric, cerebral, renal and splenic flow were pres…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.

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