THERAPY DOSSIER · th-6a192d67418a

Polyethylene glycol-conjugated superoxide dismutase plus PEG-catalase

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 2540139 ↗1989Reported benefit

Polyethylene glycol-attached antioxidant enzymes decrease pulmonary oxygen toxicity in rats.

RatOtherMalePretreatment before hyperoxic exposure

Model: Continuous hyperoxia (100% O2, 760 Torr) causing acute oxidative edematous lung injury

PEG-SOD plus PEG-CAT pretreatment prolonged survival in continuous hyperoxia to 79.1 +/- 7.6 h versus 60.7 +/- 2.1 h with saline and 62.3 +/- 1.6 h with PEG-inactivated enzymes, and reduced lung GSSG, pleural effusion and lavage albumin. Protection was less than that achieved by hypoxic preexposure…

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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