Alteration in intestine tight junction protein phosphorylation and apoptosis is associated with increase in IL-18 levels following alcohol intoxication and burn injury.
RatBurnUnspecifiedSprague-DawleyMaleAt the time of burn injury
Model: Acute ethanol intoxication by gavage (3.2 g/kg) followed by approximately 12.5 percent total body surface area burn injury
Ethanol combined with burn injury reduced total occludin and its phosphorylation and reduced claudin-1 tyrosine phosphorylation with increased mucosal apoptosis; anti-IL-18 antibody given at the time of burn prevented the apoptosis and normalised tight junction proteins.
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